What is the difference between Akriderm GK and Akriderm Genta

pharmachologic effect

• Akriderm SK is an effective combined (antiseptic + glucocorticoid) drug that has a keratolytic effect.
• The active component betamethasone dipropionate is used in the treatment of various skin diseases, including hereditary ailments.
• Salicylic acid has an antiseptic effect and also helps dissolve and gently exfoliate the top layer of skin.
• The combined effect of the above components makes it possible to use the ointment for dermatoses with pathological peeling of the upper layer of the epidermis.

Cream and ointment Akriderm Genta

This is a complex drug that contains: betamethasone, gentamicin.

Betamethasone is described above (read).

Gentamicin is a broad-spectrum antibiotic. It kills microbes that cause various purulent complications on the skin.

A medicine called Akriderm Genta is a cream with anti-inflammatory, antihistamine and antibacterial properties.

Akriderm Genta cream contains:

• Betamethasone;
• Gentamicin;
• A set of auxiliary components.

A cream is prescribed for the treatment of dermatitis, especially those secondary to bacterial microflora.

Price: 240 rub.

Contraindications

• lupus;
• perioral dermatitis;
• viral skin infections;
• rosacea;
• trophic ulcers;
• skin tumors (atheroma, nevus, skin cancer, hemangioma, melanoma, xanthoma, sarcoma, epithelioma);
• herpes simplex;
• chicken pox;
• open wounds;
• skin post-vaccination reactions;
• increased sensitivity to the substances contained in the ointment.

The ointment should not be prescribed to women during breastfeeding and to children under one year of age.

During pregnancy, can only be used under medical supervision.

Components of the drug and the specifics of their effects

– a Russian-made hormonal drug, ointment and cream are packaged in tubes of 15, 30 g. Types of medicines differ in composition and effect - this can be seen in the photo of the packaging.

The cream has a lighter structure, it is quickly absorbed and distributed in damaged tissues, cools, softens and moisturizes the epidermis. The medicine in this form is mainly prescribed for acute inflammatory processes.

The cream is absorbed faster than the ointment

The ointment is a thick, viscous substance, absorption occurs more slowly, but the therapeutic effect lasts for a long time. Doctors recommend using it for chronic dermatological pathologies and for preventive purposes; after application, a protective film is formed on the skin, which prevents pathogens from penetrating wounds.

The active components of Akriderm GK are betamethasone, gentamicin sulfate and clotrimazole:

• the first prevents inflammatory processes, stops the spread of pathogenic flora, reduces tissue permeability;
• gentamicin is an antibiotic that effectively destroys pathogens of bacterial infections;
• clotrimazole destroys the cellular structure of the fungus of most varieties and ensures restoration of the nail plate.

In addition to those listed, the drug contains additional elements. Among them are sodium dihydrogen phosphate dihydrate, cetostearyl alcohol, petroleum jelly and its extract in the form of oil, propylene glycol, macrogol ether, Trilon B.

The drug is produced in the form of an ointment for external use.

The creamy substance is transparent white (sometimes with a slight yellowish tint), there is no specific odor.

The basis of the composition is betamethasone (concentration 0.05%).

100 g of ointment contains:

• betamethasone dipropionate – 0.064 g;
• paraffin – 9 g;
• methyl parahydroxybenzoate – 0.2 g;
• propylene glycol – 5 g;
• Vaseline – 3 g;
• sodium sulfite – 0.05 g;
• emulsion wax – 7 g;
• disodium edetate – 0.1 g;
• water.

The active components of the cream are:

• antibiotic - Gentamicin sulfate (effective in the fight against Pseudomonas aeruginosa and Escherichia coli, streptococcus, etc.);
• corticosteroid - Betamethasone dipropionate (helps eliminate allergic manifestations and neutralize the inflammatory process);
• antimycotic agent - Clotrimazole (relieves fungal infections and dermotophytes);
• liquid paraffin, Vaseline;
• stearyl and cetostearyl alcohol;
• Trilon B, distilled water;
• macrogol cetostearate, propylene glycol;
• Sodium dihydrogen phosphate.

The hormonal agent can have a prolonged effect. The auxiliary components of the ointment are oil and petroleum jelly.

The ointment and cream have a characteristic white (slightly yellowish color) and a specific odor. The drug is quickly absorbed into the skin, leaving no greasy marks on the laundry.

On today's pharmacological market, Akriderm SK is presented in three dosage forms intended for external use. These are Akriderm SK ointment, Akriderm SK cream and solution, and the doctor prescribing the treatment helps you decide on the choice.

Complete information about Akriderm SK is provided by the instructions for use, where the composition of this medicinal product is clearly stated. The therapeutic effect is provided by the main drugs, and their aggressive effects are softened by auxiliary substances. Thus, the composition of Akriderm SK is represented by the following components.

Betamethasone. Active substance No. 1 from the GCS series, providing cure even in very advanced cases of skin ailments.

From a chemical point of view, this is a beta isomer of dexamethasone with one fluorine atom in the structure, it belongs to hormonal compounds. Therefore, the answer to the question: “Is Akriderm SK hormonal or not?” will be positive.

But the peculiarity of the metabolism of betamethasone is that it does not have a systemic effect and does not have an addictive effect.

Salicylic acid. The instructions for Akriderm SK describe it as an active substance that performs the functions of a keratolytic agent. In other words, this component is needed to soften and dissolve dead skin particles. At the same time, it enhances the possibility of penetration of betamethasone and gives the antibacterial effect of using Akriderm SK.

Vaseline oil, Vaseline. Auxiliary components. Their main purpose is to provide the desired consistency of the drug.

It is noteworthy that Akriderm SK and Akriderm contain the same amount of betamethasone. But, nevertheless, the therapeutic purpose is individual for these dosage forms.

The composition of the drug base is what distinguishes Akriderm from Akriderm SK: it has an emulsion base with hydrophilic properties. This cream moisturizes and prevents drying out of painful areas of the skin.

In addition, it contains compounds such as nipogin (an antimicrobial substance) and propylene glycol, which enhances the effect of GCS.

Akriderm SK in its properties is rather a hydrophobic (water-repellent) ointment that softens the affected areas. Salicylic acid works here, which is not included in Akriderm cream.

Thanks to it, the skin areas of peeling, which always form with dermatitis, psoriasis, eczema, etc., are healed.

Therefore, the presence of hyperkeratosis in a patient (increased proliferation of the stratum corneum of the skin) is the main reason to choose Akriderm SK as a treatment.

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Clinical evaluation of the drug has shown that it can be used as a monotherapy in patients with low severity of dermatitis, and in complex therapy when the skin disease has reached a moderate and high degree.

The purpose of Akriderm SK lies in its four main functions:

• relieve itching;
• remove inflammation;
• have an antihistamine effect, relieve allergic reactions.
• overcome hyperkeratosis.

It is in these processes of the drug’s influence that the therapy of the following dermatological diseases lies:

1. Psoriasis. Among medications for the treatment of this disease, the leader is Akriderm SK; reviews for psoriasis about it are extremely positive.
2. Neurodermatitis. There are two types in which the drug is effective - limited (local) and diffuse with a large affected area. In its treatment, the fat-saturating property of Akriderm SK ointment is especially valuable; reviews indicate that it is most suitable for treating patients with dry and fragile skin.
3. Lichen planus. A form of chronic dermatosis with an autoimmune nature, which is difficult to get rid of forever. Akriderm SK ointment, analogs help to achieve a high therapeutic effect in the initial manifestations and perfectly eliminate the unpleasant symptoms of itching and inflammation in later stages.
4. Eczema. The drug is suitable for the treatment of almost all forms and types, except for mycosis: Akriderm GK copes better here. The presence of an active antibiotic in the latter is what distinguishes Akriderm SK and GK.
5. Ichthyosis is also indicated for Akriderm SK. The keratolytic effect of the drug led to its use in ichthyosiform transformations, when large scales similar to fish scales form on the skin.
6. Dermatitis. The instructions for Akriderm SK ointment define the following types of illness that should be treated with it: atopic, contact, solar, occupational, etc. For seborrheic dermatitis, it is preferable to use not Akriderm SK ointment, the price of which is lower, but a solution (lotion). It penetrates well into the skin under the scalp if areas of the scalp are affected.

And this is not a complete list of what Akriderm SK ointment, cream and emulsion solution can help with. It is not uncommon for a cosmetologist to advise you to use the drug. This applies to age-related changes in the body, which are reflected on the skin of the face in the form of a purulent-inflamed rash.

The hormonal components of the ointment and lotion make it possible to effectively use Akriderm SK for acne. For dry skin, experts recommend ointment; it has a more oily texture; for oily dermis - lotion. In addition to getting rid of acne, the drug will provide protection against the development of secondary bacterial infections.

But it is important to remember the contraindications that are indicated in the instructions for use of Akriderm SK ointment and solution.

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• Hypersensitivity to individual components of the drug.
• Rosacea.
• Cancer diseases.
• Ulcers caused by venous insufficiency.
• Skin diseases of bacterial, fungal, viral background. Among them are syphilis, chickenpox, herpes, cutaneous tuberculosis and many others.

A more detailed list can be read in the instructions for Akriderm SK cream and its other dosage forms, which are necessarily included in the drug packaging.

Also, the group of patients who should not use Akriderm SK for psoriasis and other skin diseases includes expectant and nursing mothers, and infants under 1 year of age.

The rules for applying the drug imply external use only. The product, regardless of the dosage form, is applied in a thin layer three times a day.

If there is a need, occlusive dressings are applied, which are renewed once a day. The essence of such a bandage is that it prevents contact with the air and a moist chamber is formed under it.

The occlusive method of application promotes loosening of keratinization and rapid penetration of active substances.

Instructions for use of Akriderm SK (method and dosage)

The ointment is applied in a thin layer to the inflamed area of ​​the skin twice a day (morning and evening).

The duration of the therapeutic course is 21 - 30 days. If the treatment exceeds thirty days, then the medicine is applied to the affected areas of the skin once every two days.

If secondary infection of the epidermis occurs, antibacterial and antifungal treatment may be required.

For children under 12 years of age, the ointment is prescribed with extreme caution under the supervision of a physician.

Do not apply the ointment to the skin near the eyes. Also, it is not recommended to apply the above product to the skin of the face for a long period of time due to the likelihood of perioral dermatitis, skin atrophy, acne and rosacea.

It is prohibited to use the ointment in the anogenital area.

What is better Akriderm or Akriderm GK?

The differences between the two forms of release are:

1. Composition. The cream contains a larger number of auxiliary ingredients, which allows it to obtain a thick, creamy consistency. The amount of active ingredients does not differ from ointment. The indications for the use of medications are similar.
2. Method of application. The use of cream or ointment is determined by the area and type of lesion. The cream is applied to common weeping rashes. The ointment is effective for flaking and dry skin.

The differences between the two forms of Akriderm are in the composition and method of application.

Compound

The cream has the following composition:

• gentamicin – antimicrobial substance (1 mg);
• betamethasone dipropionate (64 mcg);
• clotrimazole (10 mg);
• petrolatum;
• Vaseline oil;
• cetostearyl alcohol;
• macrogol cetostearyl ether;
• trylon;
• sodium dihydrogen phosphate dihydrate;
• distilled water;
• propylene glycol;
• petrolatum.

The ointment contains:

• gentamicin (10 mg);
• clotrimazole (10 mg);
• betamethasone (64 mcg);
• petrolatum;
• Vaseline oil.

One of the indications for the use of Akriderm ointment is atopic dermatitis.

Indication for the use of Akriderm GK ointment is an allergic reaction to insect bites.

Akriderm cream is used for tinea versicolor.

Akriderm cream is used for lupus erythematosus.

Indications for use of the ointment are:

• atopic dermatitis;
• allergic contact dermatitis;
• eczema of various etiologies;
• contact dermatitis of non-allergic origin (photodermatitis, chemical and radiation dermatitis);
• allergic reactions to insect bites;
• psoriatic skin lesions;
• skin itching of various origins.

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The cream is used for:

• bullous dermatosis;
• lupus erythematosus;
• tinea versicolor;
• weeping erythema malignant;

Akriderm is not used in the presence of open wounds.

The drugs are not used for:

• tuberculous skin lesions;
• syphilitic rashes;
• chicken pox and herpes zoster;
• labial and genital herpes;
• allergic reactions caused by vaccination;
• the presence of open wounds;
• trophic ulcers caused by varicose veins;
• rosacea;
• acne and pimples;
• malignant neoplasms of the skin;
• benign tumors (atheroma, hemangioma, xanthoma);
• pregnancy and lactation;
• childhood (under 12 months).

The ointment or cream is applied to the affected areas, rubbing in with light massage movements. The procedure is carried out in the morning and evening. The duration of treatment depends on the type and severity of the disease. For dermatitis, treatment is required for at least 2 weeks. For psoriasis, the therapeutic course lasts 6-8 weeks. If there is no positive result, the drug is discontinued.

The duration of treatment depends on the type of disease. For dermatitis, treatment is required for at least 2 weeks. For psoriasis, the therapeutic course lasts 6-8 weeks.

When using the drug, the following negative reactions may occur:

• burning, redness and itching of the skin;
• inflammation of the hair follicles;
• facial hair growth in women;
• acne;
• the appearance of areas of hypopigmentation;
• allergic manifestations (erythematous skin rashes, urticaria, angioedema);
• decreased skin sensitivity;
• striae.

With long-term treatment or treatment of large areas of skin, systemic side effects are observed:

• weight gain;
• osteoporosis;
• arterial hypertension;
• swelling of the face and lower extremities;
• erosive and ulcerative lesions of the stomach and duodenum;
• sleep problems;
• increased blood glucose levels;
• exacerbation of chronic infectious diseases;
• menstrual irregularities;
• irritability.

When choosing which form of the drug to prescribe to the patient, the dermatologist takes into account the degree of damage to the skin and the presence of concomitant diseases.

If the above symptoms appear, stop treatment and consult a doctor. When a viral infection occurs, appropriate medications are used. If the infection generalizes, stop using Akriderm.

When choosing which form of the drug to prescribe to a patient, the dermatologist takes into account the degree of damage to the skin, the presence of concomitant diseases, and the condition of the skin. Sometimes the choice of drug is based on individual tolerance to the ingredients.

Svetlana, 40 years old, Moscow, allergist: “Akriderm GK ointment is highly effective and affordable. I often use it in the treatment of dermatitis and dermatoses. The drug destroys pathogenic microorganisms, preventing the addition of secondary infections. Quickly eliminates itching caused by allergic reactions. Since the ointment contains a hormonal component, it must be used with caution.”

Valentina, 46 years old, Novosibirsk, dermatologist: “Akriderm is a broad-spectrum drug that can be used for both contact dermatitis and psoriasis. When using ointments and creams in doses prescribed by a doctor, no significant side effects occur. The drug has a low price, which makes it accessible to all categories of patients. It is not recommended to apply the cream to the skin of the face.”

Doctor's reviews about the drug Akriderm and its analogues for children and adults

(2016) Akriderm® GK (ointment) preparation for external use

Angelina, 42 years old, Moscow: “My sister works as a cleaner, which is why she has to constantly wear rubber gloves. Because of this, contact dermatitis developed. The skin was peeling and itching. My sister turned to a dermatologist, who prescribed Akriderm cream. The drug helped to quickly cope with unpleasant symptoms. Periodic use of this remedy helps to avoid re-exacerbation of dermatitis.”

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Ksenia, 40 years old, Dedovsk: “My son has been suffering from allergic dermatitis since birth. Periods of calm are followed by exacerbations. During such periods, the child scratches the skin until it bleeds. The doctor advised treating the affected areas with Akriderm ointment. After using the drug, redness and itching became less pronounced. Dermatitis now worsens less frequently and does not have such an acute course.”

Dosage forms of Akriderm have exactly the same qualitative and quantitative composition of the active ingredient. They vary significantly in the content of the components that were used by manufacturers to form the base.

The patient should not choose whether to use Akriderm ointment or cream for treatment. It all depends on the doctor, who takes into account the results of laboratory tests and takes into account possible risks.

What are the main differences between the two dosage forms:

• auxiliary ingredients of the ointment ensure optimal transepidermal penetration of the active substance into the tissue;
• the ingredients for forming the cream base have therapeutic properties and alleviate the severity of symptoms.

The cream is easily absorbed and distributed in tissues damaged by the inflammatory process. And the ointment also has a preventive effect. After its application, a greasy film is formed on the skin, preventing the penetration of pathogenic microorganisms into ulcers and wounds.

Dermatologists prefer to use Akriderm cream for acute skin inflammation of various locations. This dosage form has a softening and moisturizing effect. The cream cools the skin and helps reduce the severity of clinical manifestations:

• itching and burning;
• swelling and redness;
• painful sensations.

The ointment is used most often in the treatment of chronic skin pathologies. The glucocorticosteroid penetrates into the deepest layers of the epidermis, stopping inflammation and preventing its spread. The ointment ensures maximum and long-lasting therapeutic effects on damaged tissues.

The Akriderm therapeutic line is represented by four products that differ in the content of glucocorticosteroids and other active components. Here, for example, is the difference between Akriderm and Akriderm GK:

• concentration of active ingredients, significantly higher in Akriderm GK;
• the presence in Akriderm GK of the antimycotic clotrimazole and the antibiotic gentamicin.

All varieties of the drug also have two dosage forms - cream and ointment. Which drug is suitable individually for the patient depends on the type of inflammation of the skin.

Description of the drug

The main differences between the drugs from the Akriderm group (GK, SK, Genta) lie in the qualitative and quantitative composition of the active ingredients.

They are united by the presence of a glucocorticosteroid, which explains the powerful anti-inflammatory effect of the drugs. All drugs can replace each other to one degree or another.

But maximum therapeutic activity occurs with their rational use:

• Akriderm contains only a hormonal agent and is prescribed to patients with uncomplicated skin pathologies;
• Akriderm SK composition is supplemented with salicylic acid. The drug is used in the treatment of diseases accompanied by tissue suppuration;
• Akriderm GK ointment has an antimicrobial effect due to the gentamicin it contains. The medicine is used to eliminate rashes complicated by a bacterial infection.

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The most versatile in terms of clinical action is Akriderm GK. Its multicomponent composition includes substances with antimycotic, anti-inflammatory and antibacterial activity. This allows it to be used in the treatment of skin diseases of a recurrent nature.

• Akriderm (ointment and cream) – recommended for use for psoriasis, itchy skin, etc.;
• Akriderm Genta (ointment and cream) – helps in the treatment of atopic or solar dermatitis, psoriasis, etc.;
• Akriderm GK (ointment and cream) – prescribed for the treatment of simple dermatitis, neurodermatitis, lichen;
• Akriderm SK (ointment) - helps in the treatment of psoriasis, dermatosis, lichen planus or ichthyosis.

Side effects

Sometimes Akriderm SK causes the following side effects:

• itching, burning;
• depigmentation;
• skin atrophy;
• hypertrichosis;
• acne;
• folliculitis.

With long-term use, systemic side effects sometimes appear:

• growth retardation;
• drowsiness;
• nausea, vomiting;
• Cushing's syndrome;
• pallor;
• confusion;
• hyperkalemia;
• overventilation;
• tachypnea;
• hypokalemia;
• glycosuria;
• hearing impairment;
• increased blood pressure.

Finding safe and effective drugs

The effectiveness of Akriderm GK is quite similar to Akriderm Genta - this means that the ability of the medicinal substance to provide the maximum possible effect is similar. For example, if the therapeutic effect of Akriderm GK is more pronounced, then when using Akriderm Genta, even in large doses, it will not be possible to achieve this effect.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Akriderm GK and Akriderm gents are approximately the same. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Comparison of safety of Akriderm GK and Akriderm genta

The safety of the drug includes many factors. At the same time, with Akriderm GK it is quite similar to Akriderm genta. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations.

Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Akriderm GK, as well as Akriderm genta, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Akriderm GK does not have any risks when used, just like Akriderm gents.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Akriderm GC and Akriderm genta.

Comparison of contraindications Akriderm GK and Akriderm genta

Based on the instructions. The number of contraindications for Akriderm GK is quite similar to Akriderm genta and is a satisfactory number. This is a list of symptoms with syndromes, diseases, various external and internal conditions under which the use of Akriderm GK and Akriderm genta may be undesirable or unacceptable.

Comparison of addiction between Akriderm GK and Akriderm genta

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Akriderm GC is quite similar to the similar values ​​in Akriderm genta. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body.

And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible.

At the same time, Akriderm GK has a fairly low “syndrome” value, just like Akriderm genta.

Comparison of side effects of Akriderm GK and Akriderm genta

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Akriderm GK has almost the same level of adverse events as Akriderm genta. They both have few side effects.

This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low.

The undesirable effect on the body, the strength of influence and the toxic effect of Akriderm GC is similar to Akriderm genta: how quickly the body recovers after taking it and whether it recovers at all.

Indications for use

In addition to psoriasis, Akriderm is used to treat eczema, dermatitis, etc. Regarding scaly lichen, pharmacists do not give a 100% guarantee of a complete cure for the disease, but you can still get rid of its unpleasant symptoms with the help of this remedy.

At a late stage of the disease, when there are clear signs of complications, it is recommended to use Akriderm GK ointment, which is an effective and universal ointment for psoriasis.

This drug is prescribed in the following situations:

• With the intensive appearance of new plaques, which significantly increases the lesion in a short time. Reviews about Akriderm GK for psoriasis are mostly positive. After all, with the help of the ointment it is possible to slow down uncontrolled cell division and at the same time stabilize the number of leukocytes in the area affected by the disease. This helps to reduce psoriasis lesions in a short time.
• In case of noticeable swelling of the skin that causes inflammation. Thanks to the ointment, you can quickly get rid of this problem.
• If there is severe itching, which disappears immediately after the first use.
• During the accession of secondary infections. An ointment with antifungal and antibacterial properties prevents the emergence of new serious complications.

Akriderm SK has slightly different indications for use. The main task of this drug is to exfoliate dead skin cells. People who have experienced psoriasis know that plaques rarely go away on their own. All this happens slowly and in small quantities, causing the patient to experience discomfort. With the help of salicylic acid, it is possible to dry the plaques to such an extent that they peel and fall off much faster. This is known thanks to numerous reviews about Akriderm SK ointment, which is an indispensable aid for psoriasis.